Efficient synthesis of karrikinolide via Cu(II)-catalyzed lactonization
2011
Abstract The efficient total synthesis of karrikinolide (KAR 1 ), a potent plant growth regulator discovered in smoke from burning plant material, is described. 3-Hydroxy-4-pyranone, prepared from d -xylose, was subjected to a Cu(II)-catalyzed transesterification–Wittig lactonization to afford the dihydrofuropyran in good yield. Finally, radical bromination, followed by olefin formation, provided KAR 1 in acceptable yield.
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KQI