Correlation analysis of magnetic resonance perfusion imaging and its stages of regional cerebral hypoperfusion in pre-infarction period

Objective To explore clinical value of application to magnetic resonance(MR) perfusion imaging and stages of regional cerebral hypoperfusion in preinfarction period and improve the diagnosis level for pre-infarction period,and prevent or decrease the incidence of cerebral infarction. Methods 20 cases of cerebral ischemia in case group and 20 cases of non-cerebral ischemia in control group were performed with dynamic perfusion. 197 MR images of case group were compared with 197 images of control group,calculating the ratios of illness side to normal for every image at hypoperfusion areas in the regional cerebral isehemia and referring and comparing their range provided by control group with methods of nonparametrie statistics and multivariate analysis of variance and multiple comparison. Results Four parameters of blood flow dynamics between two groups showed a significant difference (P＜0.01). Correlation coefficients between time to peak(TTP) and time to peak(MTT) and incidence of regional cereberal hypoperfusion in pre-infarction period were higher,0. 482 and 0. 471 respectively, but regional cerebralblood volume(rCBV) and regional cerebralblood flow(CBF) were lower,and also negative. The characters of stages of regional cerebral hypoperfusion in pre-infarction period were as follows: stage Ⅰ 1 ,TTP delayed slightly; stage Ⅰ 2,MTT extended markedly;stage Ⅱ 1, rCBF dropped significantly;stage Ⅱ 2, rCBV decreased. Conclusion The information of regional cerebral hypoperfusion in pre-infarction period might be provided by MR cerebral perfusion and stages of preinfarction period could be designated with the change of blood flow dynamics parameters. Key words: Brain infarction; Magnetic resonance angiography