Insulinotropic activity of chromonyl-2,4-thiazolidinediones
2009
Numerous compounds have been prepared in order to improve the pharmacological profile of insulinotropic activities. In the present paper, series of chromonyl-2,4-thiazolidinediones (Ia–e, IIa–e, and IIIa–e) were tested for their insulinotropic activities in INS-1 cells. Compounds IIb–d and IIId were very active even at a low concentration of 0.001 mg/ml. Compounds IIIa–c were active only at higher concentration (0.01 mg/ml). Increase of insulin release was observed in the presence of 5.6 mmol/l glucose.
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