The Value of Animal Assays and the Quenching Phenomenon

In the absence of in vitro models for the identification of skin sensitizers and for estimation of their potency, animal models still provide the foundation for risk assessment in this area of toxicology. In this chapter, the most commonly used models are briefly described, particularly with respect to their use in defining the potency of a particular skin sensitizer. The important points are demonstrated by a consideration of sensitizing fragrance ingredients and the quenching phenomenon.