Oxidative Conversion of Functionalized 3,4-Dihydopyrimidin-2(1H)-ones to the Corresponding Pyrimidin-2(1H)-ones Using Activated Carbon-Molecular Oxygen System
2008
Efficient synthesis of functionalized pyrimidin-2(1H)-ones was achieved by oxidation of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) using activated carbon-molecular oxygen (O 2 ) system. Various DHPMs were easily prepared by Biginelli reactions starting from aldehydes, p-ketoesters and urea. Therefore, the present method provides general and versatile protocol for the synthesis of a variety of functionalized pyrimidin-2(1H)-ones.
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