Efecto de un inhibidor tirosina kinasa (imatinib) en pacientes con tumores estromales gastrointestinales metastásicos: Experiencia preliminar

) is a selective inhibitor or tyrosine kinase proteins that has been used successfully in thetreatment of advanced GIST. We report four patients (two women) with a metastatic GIST thatwere treated with Imatinib 400 mg day and followed for 40 months. The disease tumorstabilized in three patients and in one it had an initial reduction and progressed at the end offollow up. Therefore Imatinib can be a therapeutic alternative in patients with metastatic GIST(Rev Med Chile 2007; 135: 1327-32).(