Трансформирующий фактор роста бета и некоторые цитокины в стекловидном теле пациентов с пролиферативной диабетической ретинопатией

Samples of vitreous body at patients with proliferative diabetic retinopathy (PDR) were investigated. The data obtained in research testify to existence of violations of cytokines regulation which is shown in activation of local immunoinflammatory process (reliable increase of concentration of IL-17A, IL-8, IL-6, MHF-1). It is established that not only a factor of growth of vessels endothelium, but also TGF-β2, and IL-4 possessing proliferative and fibroplastic activity are involved in processes of proliferation at PDR. The reliable increase revealed in research in vitreous body at patients with PDR of MHF-1 protein allows to make the assumption of its participation in mechanisms of vascular proliferation at the studied pathological process.