Protective Role of Pitcher of Nepenthes khasiana Hook against Dexametha-zone Induced Hyperlipidemia and Insulin Resistance in Rats

The present research was made to investigate the potential hypoglycemic and hypolipidemic effect of Nepenthes khasiana Hook in Dexamethazone-induced Hyperlipidemia and Insulin Resistance in Rats. Hypoglycemic and hypolipidemic effect of pitcher extract of Nepenthes khasiana Hook was tested at two different doses of 250 & 500 mg/kg p.o. On day 11 of treatment, blood was collected for the estimation of serum glucose and lipid parameters. Pitcher extract was compared with standard Glibenclamide at a dose of 500 mcg/kg p.o. pitcher extract and Glibenclamide significantly decreased (P<0.05) dexamethazone induced elevation of serum glucose when compared to disease control group. Pitcher extract at a dose of 500 mg/kg showed better activity than standard. The present study indicates that pitcher extract of Nepenthes khasiana Hook show significant glucose and lipid lowering activity.