Thymic Tumors and Lymphomas: The Clinical Impact of Their Underlying Molecular Features

Although rare, mediastinal tumors often present a challenge for both the physicians and the pathologists. Here we focus on the molecular features underlying thymic tumors and lymphomas, which are the most common malignancies occurring in the anterior compartment of the mediastinum. We discuss both established and recently discovered molecular alterations that can overall serve as diagnostic, prognostic, and predictive factors or possibly as targets for therapeutic intervention.