Antibiotic resistance of pathogens causing hospital-acquired septicemia in neonatal intensive care unit

OBJECTIVE To study the characteristics of the pathogens and antibiotic resistance on hospital-acquired septicemia in NICU to provide a basis for reasonable clinical administration of antibiotics.METHODS The clinical data of all the 54 cases of hospital-acquired septicemia were monitored and diagnosed in NICU in the four years from Jan 2006 to Dec 2009 and the characteristics of the pathogens and antibiotic resistance were analyzed.RESULTS 25 strains of Gram-positive bacteria accounted for 46.3%,16 cases of Gram-negative bacteria accounted for 29.6%,13 cases of fungi accounted for 24.1%;Spectrum change yearly: The ratio of G+ cocci decreased year by year,G-bacteria was increased year by year.Resistance of Staphylococcus was severe,but no vancomycin resistant strain was found.Gram-negative bacilli existed multi-drug resistant,multi-drug resistance of Acinetobacter baumannii was more prominent.CONCLUSION Pathogens of NICU nosocomial septicemia in recent years have changed,G-bacilli is increasing.Antibiotic resistance rate of hospital sepsis is high,and generally resistant to commonly used antibiotics.Strengthening the monitoring of pathogens,especially multidrug resistant pathogens,can provide the clinical basis for the reasonable use of antibiotics.