Compositions and methods for increasing bone mineralization substance.

An isolated nucleic acid molecule selected from the group consisting of: (a) an isolated nucleic acid molecule comprising SEQ ID NO. 1, 5, 9, 11, 13 or 15, or a complementary sequence thereof; (B) an isolated nucleic acid molecule that specifically hybridizes to the nucleic acid molecule of (a) under high stringency conditions where hybridization is performed in 5x SSPE, 5 x Denhardt's solution and 0.5% SDS during overnight at 55 to 60 ° C; and (c) an isolated nucleic acid encoding a protein binding to TGF-beta according to (a) and (b); wherein the nucleic acid is not the nucleic acid of any numbers AC003098 access, AA393939 and AI113131 EMBL database.