CHAPTER 5. Curcuminoids – Isolation, Formulations and Bioavailability Problems

Curcuminoids are one of the most widely studied phytochemical moieties, owing to their potential therapeutic efficiency as well as the limitations observed in their bioavailability. So far, curcumin is the derivative that is at the center of research. Despite the elucidation of the molecular and cellular mechanisms by which curcumin interacts with the signal transduction pathways of mammalian cells, many studies have been conducted, reserved for the improvement in bioavailability of curcumin after oral administration and thereby contributing towards better bio efficacy. As a result, there are a number of formulations/products developed hitherto; some of which are discussed in the chapter, including relevant examples and their effect in bioavailability. So far, there is little information in the literature on the intravenous application of curcumin. This chapter also highlights the concerns of clinical study aspects and bioavailability considerations.