Efficacy of combination therapy of tamsulosin and solifenacin for mild and moderate benign prostatic hyperplasia with overactive bladder

Objective:To evaluate the efficacy and safety of the combination therapy of tamsulosin and solifenacin for mild and moderate benign prostatic hyperplesia(BPH)with overactive bladder(OAB). Methods:We randomly divided 166 patients with BPH and concomitant OAB into a mild obstruction symptom group(n=88)and a moderate obstruction symptom group(n=78),48of the former group treated with 0.2mg tamsulosin+5mg solifenacin and the other 40with 0.2mg tam-sulosin;36of the latter group treated with 0.2mg tamsulosin+5mg solifenacin and the other 42with 0.2mg tamsulosin,all administered once daily for 12weeks.We obtained the International Prostate Symptom Score(IPSS),urine storage period symptom score(USPSS),voiding symptom score(VSS),Qmax,residual urine volume,OAB symptom score(OABSS)and adverse reactions,and compared them among different groups. Results:Among the patients with mild obstruction symptoms,the combination of tamsulosin and solifenacin achieved remarkable improvement in IPSS,USPSS,Qmax and OABSS as compared with the baseline(P 0.05),but made no significant difference in the residual urine volume(P 0.05),while tamsulosin improved IPSS only(P 0.05).The combination therapy exhibited an obvious superiority over tamsulosin alone in improving IPSS(9.7±3.0 vs 15.8±3.3),USPSS(8.1±1.7 vs 12.3±3.1),Qmax([18.6±2.3]ml/s vs[14.2± 2.3]ml/s),and OABSS(5.3±1.3 vs 9.7±2.7)(P 0.05),but there were no obvious differences in residual urine,urine routine test results and adverse events between the two therapies(P 0.05).In those with moderate obstruction symptoms,the combination therapy significantly improved IPSS,VSS,Qmax and OABSS(P 0.05)but not the residual urine(P 0.05)in comparison with the baseline.The tamsulosin therapy achieved obvious improvement in IPSS,VSS,Qmax,OABSS and residual urine.The combination therapy showed a better effect than tamsulosin only in OABSS(4.8±1.5 vs 6.5±2. 5,P 0.05),but no significant differences from the latter in IPSS,Qmax,VSS,routine urine test results,and adverse events(P 0.05). Conclusion:Combination therapy of tamsulosin and solifenacin is obviously safe and efficacious in the treatment of both mild and moderate BPH with concomitant OAB,and it is superior to tamsulosin alone.