Impaired formation of erythroblastic islands is associated with erythroid failure and poor prognosis in a significant proportion of patients with myelodysplastic syndromes

Erythropoiesis is arranged in erythroblastic islands (Ery-Is),[1][1] the specialized niche known for more than 50 years[2][2] in which erythroid precursors proliferate and differentiate. However, the significance of erythropoiesis in anemia, the leading symptom of myelodysplastic syndromes (MDS),