Steroidal Aldosterone Blockers. VIII. Hydroxylated Steroidal 17-Spirolactones

The preparation, by microbiological methods, of some derivatives of 3-(3-oxo-17β-hydroxy-4-androsten-17α-yl)propanoic acid lactone, hydroxylated at 1β, 2β, 6β, 7α, 7β, 9α, 11α, 11β, 12β, 14α, 15α, or 15β, is described as well as of two 19-nor compounds. Some of these compounds block the effects of deoxycorticosterone acetate on the rat kidney.