Levels of Factor VIIc Associated With Decreased Tissue Factor Pathway Inhibitor and Increased Plasminogen Activator Inhibitor-1 in Dyslipidemias

Abstract Tissue factor pathway inhibitor (TFPI), a kunitz-type inhibitor of the extrinsic coagulation pathway, factor VII coagulant (FVIIc), FVIIa, and the fibrinolytic factors plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (TPA) have been studied in various hyperlipidemias. Compared with a normal lipidic group, mean TFPI activity was 70% higher (P<.001) and 36% higher (P<.001) in type IIa and IIb hyperlipidemias, respectively, and was lower by 13% in type IV hyperlipidemia (P=.05). TFPI was correlated with LDL cholesterol (P<.001), total cholesterol (P<.001), HDL cholesterol (P<.01), apolipoproteins (apo) AI (P<.001) and B (P<.001) and lipoprotein a (P<.01). TFPI was negatively correlated with the triglyceride level (P<.05); the correlation was dependent on LDL cholesterol and HDL cholesterol levels, which were decreased in type IV hyperlipidemia. FVIIc activity (P<.001) was increased by 30% in both type IV and type IIb hyperlipidemia and was correlated with triglyceride level...