Formulation and Evaluation of Moxifloxacin Hydrochloride Niosomes for Controlled Ophthalmic Drug Delivery

The objective of present invesigation was to formulate and evaluate a niosomal delivery system of moxifloxacin hydrchloride for the treatment of ocular infections. Moxifloxacin-loaded niosomes were prepared by using thin film hydration technique and were investigated for surface pH, morphology, entrapment, in-vitro release, TeM (transmission electron microscopy), physical stability & ocular irritancy test. The release study profile was subjected to release kinetics models. all the vesicles were uniform and spherical in size. The drug relaese pattern of all formulation follows decreasing order: MN3 > MN6 > MN9 > MN5 > MN2 > MN1 > MN8 > MN4 > MN7. The formulation MN3 (span 60: cholesterol) molar ratio produce faster release of drug i.e. 77.98% after 12 hours, concluded less sustained action. The study concluded that the moxifloxacin loaded niosomes to be effective in sustaining the drug release leading to decreased side effects and increased patient compliance Keyword: Moxifoxacin, Niosomes, Film Hydration Technique, sustianed release.