Antitumor activity of Eugenia floccosa Bedd and Eugenia singampattiana Bedd leaves against Dalton ascites lymphoma in swiss albino mice

The aim of the present study is to evaluate the atitumor effect of Eugenia floccosa and Eugenia singampattiana (Myrtaceae) leaves against DLA bearing Swiss Albino Mice. The effect of ethanol extracts of Eugenia floccosa and Eugenia singampattiana leaves on tumor growth and host's survival time was studied by the following parameters: tumor volume, viable and non viable cell count and life span of the host. Ethanol extracts of Eugenia floccosa and Eugenia singampattiana and combined extracts of Eugenia floccosa and Eugenia singampattiana were administrated at a 100mg/Kg body weight respectively once a day for 14 days, after 24h of tumor inoculation. Decrease in tumor volume and viable count were observed. Treatment with the above said extracts increase the mean survival time. Hematological studies reveal that the Hb content was decreased in DAL treated mice, whereas, restoration to near normal levels was observed in extracts treated animals. The results suggest that the ethanol extracts of Eugenia floccosa and Eugenia singampattiana leaves exhibits significant antitumor effects in DAL bearing mice.