Efficacy and safety evaluation of Cimicifuga foetida extract in menopausal women

AbstractObjective: The aim of this study was to evaluate the efficacy and safety of long-term treatment with Cimicifuga foetida extract in menopausal women.Methods: A prospective, randomized, controlled clinical trial was conducted. A total of 96 early postmenopausal women were randomly assigned to three groups: group A received 1 mg estradiol valerate daily plus 4 mg medroxyprogesterone acetate on days 19–30; group B received 1 mg estradiol valerate daily plus 100 mg micronized progesterone on days 19–30; group C received 100 mg C. foetida extract daily. The efficacy was evaluated. Safety parameters were recorded.Results: A total of 81 patients completed the treatment and follow-up visit. The modified Kupperman Menopausal Index scores decreased after 3 months in all groups. No significant changes were observed in the liver, renal function and components of metabolic syndrome in group C (p > 0.05). There were no significant differences in the incidences of metabolic syndrome among the three groups (p > 0....