Effect of PKC-dependent Change of K+ Current Activity on Histamine-induced Contraction of Rabbit Coronary Artery

Background:Histamine, released from mast cells in atheromatous plaque, has been known to cause cardiac ischemia or sudden cardiac death in atherosclerosis patient. Previous reports have suggested that histamine induced coronary vasoconstriction was due to increase in IP 3 and DAG, which induce release of Ca 2 + from SR and increase the Ca 2 +