Non-contact measurement of heart response reflected in human eye

Abstract This study aims to develop a non-contact measurement technique for cardiac response that uses an infrared image of the patient's pupil. The pupil contraction rhythm is related to the autonomic balance and major organs (such as the heart) via a neural pathway. In this study, the response of the heart was determined by analyzing the pupillary rhythm based on the harmonic frequencies between them. Seventy undergraduate volunteers of both genders, (35 females and 35 males), with ages ranging between 20 and 30 years (mean: 24.52 ± 0.64 years) were asked to conduct a simple conversation, perform slight movements, and experience sound stimuli to evoke arousal, relaxation, happiness, sadness, or a neutral mood in this experiment. Electrocardiograms and pupil images were measured and analyzed, and the harmonic frequencies were identified to determine the relational response. The cardiac time (heart rate (HR), beats per minute (BPM), the standard deviation of the normal-to-normal (N N) intervals (SDNN), the mean squared differences in the successive N-N intervals (rMSSD), and the percentage difference between adjacent normal interbeat (R-R) intervals > 50 (pNN50)) and frequency (very low frequency (VLF), low frequency (LF), high frequency (HF), VLF/HF, and LF/HF) parameters were also observed with regard to the effects of the movement, conversation, and physiological state. The cardiac response was stable, showing less significance than the effects of the three conditions. Therefore, multi-cardiac measurements were successfully obtained from a simple, low-cost, non-invasive, and non-contact data acquisition method in this study.