Response to Letter Regarding Article, “Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest Independently of Targeted Temperature Management”

We thank Dr Wu and colleagues for their comments on our recent study comparing the efficacy of hydrogen (H2) gas inhalation and targeted temperature management (TTM) at 33°C in the treatment of post–cardiac arrest syndrome. In our study,1 rapid cooling was started 5 minutes after achieving the return of spontaneous circulation (ROSC). Rectal temperature reached 33°C within 15 minutes. The temperature was maintained for 2 hours, followed by a rewarming at a rate of 1.5°C/h up to 37°C. We believe that this experimental protocol is optimized for the following reasons. Early application of therapeutic …