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Experimental Myocardial Hypertrophy

1985 
The development of an isolated, metabolically supported working heart preparation was seminal in facilitating an experimental approach to heart disease. In a working frog heart, Frank [1] noted that isovolumic ventricular pressure development increases with an increase in filling pressure as does the amount of fluid ejected with each beat. Frank also noted that as diastolic hydrostatic pressure increased, isovolumic ventricular pressure or ventricular ejection volume reached a maximum and then declined. Consequently, Frank came to the conclusion that end-diastolic volume and myocardial fiber length are important determinants of subsequent systolic activity, although he did not measure ventricular volume directly.
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