Transgenic mouse capable of over-expressing vascular endothelial protein tyrosine phosphatase (ve-ptp)

The present invention relates generally to a transgenic mouse. In particular, the present invention relates to a transgenic mouse whose genome comprises a tetracycline operon- Vascular Endothelial Protein Tyrosine Phosphatase (TetO-VE-PTP) transgene. The present invention also relates to a double transgenic mouse whose genome comprises the transgenes TetO-VE-PTP and Tie2-tTA, which is capable of conditionally over-expressing VE-PTP which is contingent on the presence of doxycycline. The present invention also relates to methods of generating a transgenic mouse whose genome comprises a TetO-VE-PTP and a double transgenic mouse whose genome comprises the transgenes TetO-VE-PTP and Tie2-tTA.