MP70-04 ASSOCIATION OF MODIFIABLE AND NON-MODIFIABLE RISK FACTORS WITH PERINEPHRIC ADIPOSE TISSUE: IMPLICATIONS FOR PARTIAL NEPHRECTOMY

METHODS: We performed a multi-institutional retrospective review of 1240 patients undergoing PN (open or laparoscopic) for localized renal malignancy between from 2002 to 2013. Recurrencefree survival was estimated using the Kaplan-Meier method and evaluated as a function of PSM with log-rank test and Cox proportional hazards models adjusting for tumor size, grade, histology, pathologic stage, focality, and laterality. Site of recurrence (local or distant) as a function of PSM was tested with Fisher’s exact test. RESULTS: A total of 97 (8%) patients had PSM. PSM was unrelated to tumor size, grade, histology, pathologic stage, focality or laterality (all P > 0.05). A total of 69 (6%) patients developed recurrence over a median follow up of 33 months (interquartile range [IQR] 1⁄4 1557). Of these, 42 (61%) were local and 27 (39%) were distant recurrences. The median time to recurrence was 19 months (IQR 1⁄4 1235). On univariable analysis, PSM was associated with higher recurrence rates (Figure, P 1⁄4 0.002). On multivariable analysis, PSM remained associated with higher recurrence rates (hazard ratio 1⁄4 2.91, 95% confidence interval 1⁄4 1.25-6.78, P 1⁄4 0.013). PSM was not associated with site of recurrence (P 1⁄4 0.52). CONCLUSIONS: PSM is associated with an increased risk of recurrence after PN. Urologist should strive to obtain negative surgical margins in order to maximize disease-free survival. For patients with PSM, close follow-up is advisable given their higher risk of disease recurrence.