The origin of cynomolgus monkey affects the outcome of kidney allografts under Neoral immunosuppression.

YNOMOLGUS monkeys are found in various sources around the world, and the influence of the origin of these monkeys on the outcome of transplantation (TX) experiments is not clear. This study aimed at comparing the effects of cyclosporine (CsA) on kidney allograft survival in cynomolgus monkeys from two distinct locations: from the Philippines (Siconbrec Ltd) and from Mauritius (CRP Ltd). METHODS The study was performed in accordance with the Swiss Animal Welfare regulations. Donor-recipient combinations were selected according to ABO blood group compatibility and MHC mismatch as assessed by in vitro mixed lymphocyte reaction (MLR stimulation index 10). Life-supporting kidney allograft TX were performed within these two populations. Recipients were treated post-TX with Neoral daily orally using two different regimens: R1, 150 mg/kg/d for 15 days followed by 100 or 75 mg/kg/d; R2, 100 mg/kg/d for 15 days followed by 30 mg/kg/d. 1,2 Graft function was followed by monitoring changes in serum creatinine (Screa). Screa levels 500 mol/L were considered indicative of rejection, which was confirmed histologically. RESULTS