Long‐Term Cardiac Function After Peripartum Cardiomyopathy and Preeclampsia: A Danish Nationwide, Clinical Follow‐Up Study Using Maximal Exercise Testing and Cardiac Magnetic Resonance Imaging

Background Long‐term clinical studies of peripartum cardiomyopathy (PPCM) are few. We aimed to measure the long‐term effect of PPCM on cardiac function in comparison with the long‐term effects of severe preeclampsia and uncomplicated pregnancy. Methods and Results A nationwide Danish cohort of women diagnosed with PPCM from 2005 to 2014 (PPCMgroup) were invited to participate in a clinical follow‐up study including maximal cardiopulmonary exercise testing and cardiac magnetic resonance imaging. Matched women with previous severe preeclampsia (preeclampsia group) and previous uncomplicated pregnancies (uncomplicated pregnancies group) served as comparison groups. A total of 84 women with 28 in each group participated. Median time to follow‐up after PPCM was 91 months. Most women (85%) in the PPCM group reported no symptoms of heart failure. Mean left ventricular ejection fraction in the PPCM group was normal at 62%, but significantly lower than in the preeclampsia group and the uncomplicated pregnancies gr...