Inhibition of serum amyloid A RNAi for treating glaucoma
2005
Composition comprising an effective amount of interfering RNA having a length of 19 to 49nucleotidos and a pharmaceutically acceptable carrier, the interfering RNA comprising: unasecuencia nucleotide sense, an antisense nucleotide sequence and a region of at least EL80% complementarity adjacent at least 19 nucleotides between the sense sequences yantisentido; wherein the antisense sequence hybridizes under physiological conditions to a delARNm portion corresponding to SEQ ID NO: 1 or SEQ ID NO: 2, and has a region of at least 80% decomplementariedad adjoining at least 19 nucleotides with the part hybridizing mRNA correspondea SEQ ID NO: 1 or SEQ ID NO: 2 for use in the treatment of glaucoma associated with serum amyloid Aen an eye of a subject.
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