Activation of classical protein kinase C reduces the expression of human cationic amino acid transporter 3 (hCAT-3) in the plasma membrane

,54185–54192]. However, others found increased transport ratesfor arginine in response to PKC activation, suggesting a differ-ential effect of PKC on different CAT isoforms. Therefore we in-vestigated the effect of PKC on hCAT-3, an isoform expressedin thymus, brain, ovary, uterus and mammary gland. In