Compounds and methods for modulating expression PCSK9

A short 10 to 16 monomers linked length comprising a region of 2'-deoxyribonucleotides huecode flanked on each side by one end, wherein each end comprendeindependientemente 1 to 3 high-affinity modified monomers selected from bicyclic nucleotides or antisense compound otrosnucleotidos 2'modified and wherein the short antisense compound is chosen as target for encoding PCSK9 acidonucleico.