Синтез индолсодержащих соединений 2-тиобарбитуровой кислоты

The synthesis of barbituric acid derivatives containing a phenylskatyl residue substituted at C5 is described. The initial compound was α-phenylnorgramine, which had been previously successfully used for the alkylation of a series of CH-acids, in particular, for the synthesis of diethyl-1H-indol-3-yl(phenyl)methylmalonate. This compound has been used to obtain a series of 2-thiobarbituric acid derivatives, which are expected to possess antioxidant, membrane protector, and radioprotector properties.