Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer

Kisho Ono,Chiharu Sogawa,Hotaka Kawai,Manh Tien Tran,Eman A. Taha,Yanyin Lu,May Wathone Oo,Yuka Okusha,Hirohiko Okamura,Soichiro Ibaragi,Masaharu Takigawa,Ken-ichi Kozaki,Hitoshi Nagatsuka,Akira Sasaki,Kuniaki Okamoto,Stuart K. Calderwood,Takanori Eguchi

Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer

2020

Kisho Ono
Chiharu Sogawa
Hotaka Kawai
Manh Tien Tran
Eman A. Taha
Yanyin Lu
May Wathone Oo
Yuka Okusha
Hirohiko Okamura
Soichiro Ibaragi
Masaharu Takigawa
Ken-ichi Kozaki
Hitoshi Nagatsuka
Akira Sasaki
Kuniaki Okamoto
Stuart K. Calderwood
Takanori Eguchi

Evidence has been accumulating to indicate that extracellular vesicles (EVs), including exosomes, released by cancer cells can foster tumour progression. The molecular chaperones – CDC37, HSP90α an...

Keywords:

Cancer
Cancer cell
Chaperone (protein)
Cancer research
Malignancy
Microvesicles
Gene knockdown
Tetraspanin
Chemistry
Epithelial–mesenchymal transition

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