Mg2+ ion effect on phase equilibrium in polyA·polyU and polyA·2polyU

Noncanonical structures of nucleic acids are involved in main biological reactions. To identify cell mechanisms of structural reconstructions in nucleic acids is a key problem of molecular biology. One of the factors having an influence on the stability of different structures is the ion environment. Na+ effects on structural transitions in such molecules as polyApolyU are well studied and phase diagrams are built [1]. The present work was aimed at building of the complete phase diagram for polyApolyU, polyA-2polyU complexes with Mg2+ at different ionic strengths.