Bendiocarb-induced nephrotoxicity in rats and the protective role of vitamins C and E

Bendiocarb is a pesticide carbamate which is used to protect agricultural products and animals. In this study, rats were given orally with bendiocarb and also other chemicals via gavage. Male rats were randomly divided into eight groups (n = 6): group 1 served as controls; group 2 received vitamin C (100 mg/kg bw); group 3 received vitamin E (100 mg/kg bw); group 4 received vitamins C plus E; group 5 received bendiocarb (0.8 mg/kg 1/50 LD50); group 6 received both bendiocarb and vitamin C; group 7 received both bendiocarb and vitamin E; and group 8 received both bendiocarb and vitamin C and E via oral gavage. Degenerative changes and biochemical differences in rat kidney were investigated after 4 weeks of especially bendiocarb treatment. While biochemical values were normal in the control group, it was observed that CAT, SOD, GPx, and GST values decreased, while MDA, creatine, urea, and uric acid values increased in the pesticide-treated groups. It was also reported that bendiocarb caused cytopathological and histopathological changes in rat kidney. We have shown that the application of vitamins has a therapeutic effect on the evaluated parameters.