Helicobacter pylori in patients with disorders of hepatobiliary system

Abstract Detection of H. pylori in gastric mucosa, bile-excreting ducts, livertissue, and bile of patients with different disorders hepatobiliary system (HBS). Seventy-six patients (52 females and 24 males) with following diagnoses: chronic noncalculous cholecystitis (25 patients), gallstone disease (28), liver cirrhosis (12), ischemic heart disease (control group, n = 11), admitted to hospitals in Kazan and Zelenodolsk (Republic of Tatarstan), were examined. Mean age of the patients was 56.5 years. Samples of bile as well as tissues of liver, bile ducts and gastric mucosa were used as materials for tests. Polymerase chain reaction and culture method were used for H. pylori detection. Analysis of obtained results showed association of clinical diagnosis and presence of H. pylori DNA in bile ducts mucosal epithelium. H. pylori was significantly more frequently detected in epithelium of bile ducts mucosa (66.7 +/- 13.6%) and bile(56 +/- 9.9%) than in liver tissue (33.3 +/- 13.6%) (p