Specificity of human cytotoxic responses to chemically modified autologous cells.

: Human PBML can generate cytotoxic responses to autologous cells that have been chemically modified with TNP or DNP. The cytotoxic effectors have precise hapten specificity. The DNP-specific effectors recognize DNP in association with cell surface alloantigens, which appear to be at least partially associated with HLA-A and -B. The TNP-specific effectors recognize TNP in association with several classes of determinants--some of which are HLA-linked alloantigens that are incompletely associated with HLA-A and -B, while other determinants are widely shared among humans.