Heroin Fatality in a Feline: A Case Report with Postmortem Liver Concentrations.

A case of feline intoxication and fatality with the illicit drug heroin is described. A five-year-old castrated male domestic short hair cat was recently diagnosed with an active pneumonitis and left at home for a couple days under the care of another resident. Upon return, the owner found his cat dead with strong suspicion of foul-play. The cat was necropsied by a local veterinary clinic to retrieve the liver for diagnostic toxicology. The postmortem liver sample screened positive for 6-acetylmorphine and 6-acetylcodeine by gas chromatography mass spectrometry (GC-MS). Deconvolution techniques were applied to chromatograms and revealed the additional presence of morphine and mirtazapine. Subsequent quantitation of mirtazapine, heroin, morphine, 6-acetylmorphine, 6-acetylcodeine was performed by gas chromatography tandem quadrupole mass spectrometry (GC-MS/MS). Although companion animal fatalities arising from toxicities are a likely consequence of drug abuse in a home, this is the first reported case of a malicious feline fatality resulting from heroin with quantitation of heroin metabolites.