A Packaged Ingestible Bio-Pill with 15-Pixel Multiplexed Fluorescence Nucleic-Acid Sensor and Bi-Directional Wireless Interface for In-Vivo Bio-Molecular Sensing

This paper presents the first wireless multiplexed fluorescence-based bio-molecular sensing system in a pill form for GI-track health monitoring application. This application is geared towards quasi-real time analysis of microbiome distribution through nucleic acid detection. A silicon chip integrates both the sensor and the wireless system, including a 124 μW ULP wireless receiver with −59 dBm sensitivity, a dual mode FSK/OOK transmitter, and a fluorescent sensor array with 1.6 attomoles and 100 pM of target DNA detection limit per pixel. The complete package includes a CMOS fluorescent sensor chip with integrated filter, a prototyped UV LED and optical waveguide, functionalized bioslip, off-chip power management and Tx/Rx antenna that fits in a standard FDA approved capsule size 000.