Development of mitochondrial targeted theranostic nanocarriers for treatment of gliomas

Abstract Theranostic nanoparticles were developed using synthesized Gadolinium doped iron oxide nanoplatforms by polyol process. Lenalidomide was coated on the magnetic core using PLGA by nanoprecipitation technique. Modification of Polyethylenimine was done with targeting moieties to provide targeting against gliomas. The cell line studies were performed on U87MG glioblastoma cell lines. Toxicity evaluation was done by mucosal toxicity study and hemolysis test. The magnetic core had ultra-small particle size of