Clinical spectrum of uveal metastasis in Korean patients based on primary tumor origin.

Abstract Purpose To describe the clinical features and prognosis of patients with uveal metastasis in Korea. Design Retrospective observational case series. Subjects Patients diagnosed at two tertiary high-volume centers between November 2005 and November 2019. Methods Evaluation of multimodal imaging and electronic records. Main Outcome Measures The clinical features and outcomes were assessed based on the primary cancer site. Results A total of 134 uveal metastases (128 choroidal, 3 iris, 3 ciliary body tumors) were diagnosed in 95 eyes of 80 patients. Mean age at diagnosis was 56 years (median 55, range 24-86), with a minor female preponderance (61%). Tumors were bilateral in 15 (19%) patients and the primary origin was established in 49 (61%) patients prior to ocular detection. The primary tumor originated in the lung (48%), breast (24%), gastrointestinal (GI) tract (10%), liver (3%), pancreas (3%), kidney (1%), cervix (1%), and nasopharynx (1%), with some remaining unknown (10%). The overall 5-year survival rate was 21%. Kaplan-Meier analysis revealed that the worst survival was found in pancreatic cancers (mean survival: 5.9 months, P=0.045) and the best with GI tract cancers (44.5 months). Conclusion The primary tumor origin in Korean patients with uveal metastases differs from those reported in primarily Caucasian population-based studies, with a higher prevalence of lung and GI tract cancers.