Resistance-modifying agents. Part 7: 2,6-Disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of α1-acid glycoprotein (AGP)

Hc Barlow,Karen J. Bowman,Nicola J. Curtin,A. Hilary Calvert,Bernard T. Golding,Bing Huang,Peter J. Loughlin,David R. Newell,Peter G. Smith,Roger J. Griffin

Resistance-modifying agents. Part 7: 2,6-Disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of α1-acid glycoprotein (AGP)

2000

Hc Barlow
Karen J. Bowman
Nicola J. Curtin
A. Hilary Calvert
Bernard T. Golding
Bing Huang
Peter J. Loughlin
David R. Newell
Peter G. Smith
Roger J. Griffin

Abstract The synthesis and biological evaluation of potent 4,8-dibenzylaminopyrimidopyrimidine nucleoside transport inhibitors, with reduced binding to α 1 -acid glycoprotein, is reported.

Keywords:

Orosomucoid
Nucleoside
Organic chemistry
Biochemistry
Glycoprotein
Antimetabolite
Chemistry
Bicyclic molecule
Chemical synthesis
Stereochemistry
α1 acid glycoprotein
In vitro
biological evaluation

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