Mortality Predictors in Bacterial Meningitis Patients who developed Hydrocephalus (P5.050)

OBJECTIVE: To identify predictors of mortality in bacterial meningitis who developed hydrocephalus. BACKGROUND: Hydrocephalus is a major complication of bacterial meningitis and can increase mortality. DESIGN/METHODS: Retrospective search of Nationwide Inpatient Sample (NIS) was done to identify patients with primary diagnosis of bacterial meningitis (ICD-9 code 320.x, 320.xx) who also had hydrocephalus (ICD-9 codes 331.3, 331.4). Patients with secondary diagnosis of intracranial hemorrhage, traumatic brain injury, brain tumor or brain metastasis were excluded in order to minimize nosocomial and iatrogenic bacterial meningitis cases from the sample. Complications were identified using their respective ICD-9 codes. Patients who underwent ventriculostomy were identified (ICD-9-CM procedure code 02.2). Multivariate logistic regression was used to identify predictors of mortality. RESULTS: Total 333 patients with bacterial meningitis who had hydrocephalus were found from year 2000 to 2011. Out of which 97 (29.1[percnt]) required ventriculostomy. There were 62 (18.7[percnt]) inpatient deaths. In multivariate analysis, every decade increase in age, ischemic stroke, respiratory failure and requirement of ventriculostomy were significant predictors of mortality. CONCLUSIONS: In this retrospective analysis, we found that every decade increase in age, ischemic stroke, respiratory failure and requirement of ventriculostomy were significant predictors of mortality in patients of bacterial meningitis who developed hydrocephalus. Study Supported by: Disclosure: Dr. Irshad has nothing to disclose. Dr. Modi has nothing to disclose. Dr. Naqvi has nothing to disclose. Dr. Dharaiya has nothing to disclose.