Antifilarial activity of Argyria speciosa against Setaria cervi in vitro

1990 
The effect of aqueous and alcoholic extracts of Argyria speciosa on the spontaneous movements of both the whole worm and a nerve/muscle preparation of Setaria cervi, and on the survival of microfilariae in vitro, was studied. Both extracts caused the inhibition of spontaneous movements of the whole worm and the nerve/muscle preparation of S. cervi, characterized by decrease in tone, amplitude and rate of contractions. The concentration required to inhibit the movements of the whole worm preparation was 150 μg/mL for the aqueous, and 75 μg/mL for the alcoholic extract. The concentration of A. speciosa extract required to produce an equivalent effect on the nerve/muscle preparation was 25 μg/mL for aqueous, and 50 ng/mL for the alcoholic extract.
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