[Factor VIII inhibitors in non-hemophiliac patients. A report of cases and therapeutic prospects].

: Approximately 5-20% of patients with hemophilia A acquire antifactor VIII antibodies during transfusion therapy. These autoantibodies cause serious bleeding and are rarely found in non hemophiliac patients (only a few hundred case reports in the literature). Treatment of this autoimmune condition is quite difficult: corticosteroids, immunosuppressive agents, plasmapheresis and transfusions may be useful. We describe two patients we observed and add some general reflections on therapy.