Effect of starvation on brain glucose metabolism and 18F-2-fluoro-2-deoxyglucose uptake: an experimental in-vivo and ex-vivo study

Ambra Buschiazzo,Vanessa Cossu,Matteo Bauckneht,Annamaria Orengo,Patrizia Piccioli,Laura Emionite,Giovanna Bianchi,Federica Grillo,Anna Rocchi,Francesco Di Giulio,Francesco Fiz,Lizzia Raffaghello,Flavio Nobili,Silvia Bruno,Giacomo Caviglia,Silvia Ravera,Fabio Benfenati,Michele Piana,Silvia Morbelli,Gianmario Sambuceti,Cecilia Marini

Effect of starvation on brain glucose metabolism and 18F-2-fluoro-2-deoxyglucose uptake: an experimental in-vivo and ex-vivo study

2018

Background The close connection between neuronal activity and glucose consumption accounts for the clinical value of 18F-fluoro-2-deoxyglucose (FDG) imaging in neurodegenerative disorders. Nevertheless, brain metabolic response to starvation (STS) might hamper the diagnostic accuracy of FDG PET/CT when the cognitive impairment results in a severe food deprivation.

Keywords:

Deoxyglucose
In vivo
Ex vivo
Neuroimaging
Endocrinology
Carbohydrate metabolism
Internal medicine
Premovement neuronal activity
Biology
Phosphorylation
Medicine
Incubation
Skeletal muscle

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