Experimental Study on Effect of Sanmiao Mixture Capsules on Prostate Hyperplasia in Mice and Rats

Objective:To observe the effect of Sanmiao Mixture Capsules(SMC)on prostate hyperplasia in mice and rats.Method:The model of prostate hyperplasia was made by injecting testosterone propionate in to male mice(5g·kg -1 ·d -1 ,21d)and rats(3g·kg -1 ·d -1 ,14d).The treated group was administered SMC(mice:36.3g·kg -1 and 18.2g·kg -1 ;rats:25.2g·kg -1 and12.6g·kg -1 ),the normal control group 1.9g·kg -1 ,and the model control group NS. hours after the last administration serum tests were carried out on E 2, AKP and Zn 2+ .Then the animals were killed,prostates taken out and weighed,index of prostate was calculated and pathological examination performed .Result : In the SMC treated group,the prostate weight and index were lowered( P 0.01) the mean activation of E 2 was raised,and the mean concentration of AKP and Zn 2+ was inhibited ( P 0.01).Conclusion:SMC are helpful in checking prostate hyperplasia in mice and rats,the mechanism being probably related to the raising of activation of E 2 as well as to the inhibition of concentration of AKP and Zn 2+ . [