Development of Manufacturing Processes for the Carboxylic Acid Key Intermediate of Lusutrombopag: One-pot Reaction Process of Formylation and Horner-Wadsworth-Emmons Reaction

We describe the development of a one-pot preparation process of (E)-3,5-dichloro-4-(3-ethoxy-2-methyl-3-oxoprop-1-en-1-yl)benzoic acid (3), which is a key carboxylic acid intermediate of lusutrombo...