FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED RELEASE TABLETS OF GLIPIZIDE

The aim of the present study was to develop Sustained release formulation of Glipizide to maintain constant therapeutic levels of the drug for over 12 hrs. Here different types of polymers (Locust Bean Gum, Gum Cyamposis, Corn Sugar Gum) were used. Glipizide dose was fixed as 10 mg. Total weight of the tablet was considered as 100 mg. Polymers were used in the concentration of 10, 20 and 30 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that Among all formulations F2 formulation was considered as optimised formulation. It was shown 99.65% drug release at 12 hrs. The optimised formulation F2 was followed Higuchi release kinetics