viable bacterial densities. New turbidimetric assay for quantitation of

againstE. coli.The MIC is the most commonly used measurement toquantitate the antimicrobial effect of antibiotics. However,this endpoint provides little information onthe time-depen-dentchangesofabacterialpopulationduringincubationwiththe antibiotic. Time-kill studies, which rely solely on thepour plate and colony-counting assay, remain the only