RAPID COMMUNICATION ALCOHOL INTAKE AFTER SEROTONIN TRANSPORTER INACTIVATION IN MICE

Knock-out mice lacking the serotonin transporter (5-hydroxytryptamine transporter (5-HTT)) were used to assess the influence of 5-HT re-uptake on ethanol consumption. Under a free-choice paradigm, alcohol intake was lower in mutant than in wild- type mice, and pharmacological blockade of 5-HTT by fluoxetine reduced alcohol intake in wild-type mice only. These data confirm the inhibitory effect of 5-HTT inactivation on ethanol intake.